Most common cause is coronary arteriosclerosis.
Other causes: 1. Relative coronary insufficiency due
to cardiac hypertrophy due to hypertension, valvular
disease, or unknown causes. 2. Healed rheumatic
myocarditis. 3. Healed multiple micro-infarcts due to
emboli from vegetations of an infectious endocarditis.
4. Healed infectious, immune, toxic, or idiopathic
myocarditis. 5. Scleroderma.
Coronary occlusive disease and/or cardiac hypertrophy
result in chronic ischemia with necrosis and fibrosis.
Repeated attacks of angina pectoris each represent a
micro-infarct, with the evolution of confluent
Other causes cause myocardial necrosis directly and
heal as scars.,
Varies with different underlying causes.
|General Gross Description|
Scars due to occlusive or relative coronary
insuffuciency are typically subendocardial.
Scars due to myocarditis of diverse etiologies
are more random.
Focal Scarring due to scleroderma is uniformly
|General Microscopic Description|
The histology of scarring is non-specific, and of no
value to the determination of etiology.
Scar consists of fibroblasts and collagen
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 523-566.
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|Synopsis by: J. Hasson, MD (T33010M49000)