| Metastatic Adenocarcinoma
|
Etiology
• In women most common origin of clinically
significant metastatic disease is breast
• In men metastatic neoplasms from the GI tract are most often clinically
significant
|
Pathogenesis
• Tumor thrombi arrive via venous drainage of the carcinoma, circulate
through the heart and lodge in small pulmonary vessels,
|
Epidemiology
• All carcinomas can
spread to the lungs.
|
General Gross Description
• Usually
multifocal lesions scattered through the periphery of the lung
• May be more frequent in the lower lobes where blood supply is richer
• Well circumscribed nodules or
• Fills subpleural and intrapulmonary lymphatics with gray white neoplasm
or
• Grossly inapparent
•Examples:
|
General Microscopic Description
• Dependent on cell and organ of origin.
•Examples:
|
Clinical Correlation
• Presence of pulmonary
metastases usually indicates ominous prognosis.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 727-8.
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| Metastatic Adenocarcinoma
| | Synopsis by: Melinda Sanders M.D. (T28000M80106)[141]
| |