| Small Intestinal Atresia
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Etiology
• Unknown.
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Pathogenesis
• Theories include:
• Failure to recanalize solid lumen leading to single area of atresia or multiple sites
• Ischemia due to mechanical obstruction such as intussusception
• Meconium ileus leading to inflammation and obstruction,
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Epidemiology
• Duodenal atresia in 1:5000 live births; frequently associated with Down's syndrome or other anomalies
• Jejuno-ileal atresia ranges from 1:1500 to 1:20,000; usually not associated with other anomalies
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General Gross Description
• Most duodenal atresia either exhibits a mucosal membrane or two lumens connected by a cord
• Jejuno-ileal atresia may show these patterns or multiple isolated segments.
•Examples:
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General Microscopic Description
• Variety of histologic pictures; may be inflammation, meconium extravasation and fibrosis or may simply be an absence of lumen or entire bowel wall.
•Examples:
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References
• Dimmick JE, Kalousek DK. Developmental Pathology of the Embryo and Fetus. Philadelphia: Lipincott. 1992. pp. 519-524.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. pp. 787.
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| Small Intestinal Atresia
| | Synopsis by: Melinda Sanders M.D. (T64000M20400)[533]
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