Gliadin, a protein component of gluten, found in wheat, oats, barley and rye.
Anti-endomysin antibody and anti-gliadin (AGA) antibodies
Gamma-delta TCR (T-cell-receptor)-bearing intraepithelial lymphocytes present in increased numbers (? response to antigen-antibody complex),
Generally in Caucasians.
Prevalence: 1 in 2000-3,000
Associated with HLA-DR3 and HLA-DQw2
Concordance of 70% in identical twins.
|General Gross Description|
Flattened mucosal surface
|General Microscopic Description|
Loss of villus architecture
Increased plasma cells and lymphocytes in lamina propria
Diffuse process, more severe in proximal portion of small bowel.
Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, pp. 1313.
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 797-8.
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||Synopsis by: Melinda Sanders M.D. (T64000D62180)