Cytomegalovirus, beta-group herpesvirus
Viral infection of endothelium and epithelial cells as well as stromal cells
Productive infection results in viral cytopathic changes described below
Endothelial cell damage can lead to vascular injury,
Widely distributed in normal population where it is acquired sexually, perinatally, in breast milk, intrauterine or by respiratory droplets
Causes asymptomatic or mononucleosis like infection; latent in leukocytes
In immunocompromised patient's becomes disseminated
|General Gross Description|
Discrete ulcers when endothelial cell involvement pronounced.
|General Microscopic Description|
Cytopathic changes associated with viral infection and replication include marked cellular enlargement.
Large intranuclear and/or intracytoplasmic eosinophilic inclusions
Intranuclear inclusions occupying >50% of nuclear diameter are diagnostic
Necrosis with endothelial cell involvement
Diagnostic Surgical Pathology, 2d edition, Sternberg SS (ed). Philadelphia: Lippincott-Raven,1996, pp. 1335.
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||Synopsis by: Melinda Sanders M.D. (T64000E32230)