|Normal Colonic Mucosa|
|General Gross Description|
Consists of cecum, ascending colon which is attached to the retroperitoneum; hepatic flexure and transverse colon which are supported by gastrocolic ligament; splenic flexure, descending colon with retroperitoneal attachment; sigmoid colon, and rectum which have an extraperitoneal component.
All show similar mucosal surface
Supplied by superior mesenteric artery to splenic flexure, inferior mesenteric artery to distal rectum
Distal rectum supplied by branches of the internal iliacs
Venous drainage is predominantly via the portal system to the liver although systemic drainage occurs in distal rectum
Lymphatic drainage to regional nodes.
|General Microscopic Description|
Epithelium composed of a mixture of columnar absorptive and goblet cells covering the surface and extending into crypts
Occasional lymphocytes, eosinophils, and apoptotic cells found in surface epithelium, as well as endocrine cells and Paneth cells in proximal right colon and cecum
Crypts extend from surface to muscularis mucosae and are surrounded by lamina propria containing plasma cells, T lymphocytes, mast cells, fibroblasts, eosinophils and macrophages
Lymphocytes may be dispersed or arranged in lymphoid follicles that may extend through muscularis mucosae to submucosa.
Lymphatics are found in mucosa just adjacent to the muscularis mucosae.
Submucosa contains Meissner's plexus of ganglion cells and nerve fibers
Inner circular layer and outer longitudinal layer of muscle with Auerbach's plexus between them
Serosa and or pericolic fat
Histology for Pathologists. Sternberg SS ed. New York: Raven Press, 1992. pp. 573-582.
This link will directly take you to the relevant new literature
|Normal Colonic Mucosa
||Synopsis by: Melinda Sanders M.D. (T67000M00100)