| Necrosis
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Etiology
•Necrosis of the liver cells is seen with many different
disorders affecting the liver.
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Pathogenesis
•Coagulation necrosis of the liver cell may follow from
vascular compromise as in thrombosis of the hepatic
artery or from right-sided heart failure.
•Certain toxic injuries, on the other hand, result in
apoptosis and give rise to characteristic cells with
deeply eosinophilic cytoplasm and a pyknotic nucleus
(Councilman bodies).
•Necrosis due to vascular or toxic injury generally
affects the centri-lobular area.
•Periportal necrosis occurs in eclampsia and in
phosphorous toxicity.
•Mid-lobular necrosis is rare.,
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Epidemiology
•Not uncommon
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General Gross Description
•Grossly, the liver with large areas of necrosis may
appear shrunken and yellowishdue to the
necrosis.
•Focal necrosis may appear as focal areas of yellowish
discoloration visible on cross section.
•Examples:
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General Microscopic Description
•Microscopically, toxic liver injury characteristically
causes apoptosis with shrunken cells, which are deeply
eosinophilic, with a disintegrating nucleus.
•Truly necrotic cells, on the other hand, go through a
phase of "hydropic degeneration" followed by rupture of
the cell.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 833
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| Necrosis
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T56000M54000)[596]
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