| Adenocarcinoma
|
Etiology
•Cancer of the gallbladder is strongly associated with
stone disease.
•Even in patients with gallstones, the risk of carcinoma
is low.
|
Pathogenesis
•Unknown,
|
Epidemiology
•Approximately 6,000 new cases of adenocarcinoma of the
gallbladder are diagnosed in the United States per year.
•The male to female ratio is 4.1.
•The mean age at the time of diagnosis is 70 years.
|
General Gross Description
•Grossly, carcinoma of the gallbladder can either
extend centrifugally, infiltrating into the wall of the
gallbladder or be exophytic, growing as a fungating
mass into the cavity of the bladder.
•Examples:
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General Microscopic Description
•Most carcinomas of the gallbladder are well
differentiated adenocarcinomas.
•Other forms include papillary variety, poorly
differentiated, or with squamous metaplasia.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 891
• Harrison's Principles of Internal Medicine, 13th Ed: Isselbach et. al. (eds). New York, McGraw-Hill, 1994, pp.1512
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| Adenocarcinoma
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T57000M82603)[583]
| |