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| Pancreatic Adenocarcinoma | ||
| Etiology • Unknown | ||
| Pathogenesis •Unknown, | ||
| Epidemiology • 5% of cancer deaths • More common in men and African-Americans • More common in diabetics • Patients >50 • Incidence is increasing • Associated with smoking, fatty diet, and partial gastrectomy | ||
| General Gross Description • May be firm gray white lesions with obliteration of underlying architecture • May be subtle and detected only by feel • Smaller lesions more common in head; larger diffuse lesions predominate in tail where symptoms develop later •Examples: | ||
| General Microscopic Description • Usually composed of small ductules or tubules with pleomorphic nuclei, prominent nucleoli and scant cytoplasm • Generally dense fibrous stroma •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 905-7. This link will directly take you to the relevant new literature Pancreatic Adenocarcinoma
| Synopsis by: Melinda Sanders M.D. (T59000M81403)[344]
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