| Lupus Nephritis
|
Etiology
•Unknown
|
Pathogenesis
•Production of autoimmune antibodies to many self antigens
especially antinuclear antibodies.
•Production of antibodies to kidney
antigens plus the accumulation of circulating immune complexes in the
glomeruli lead to renal injury.,
|
Epidemiology
•SLE is
predominantly a disease affecting women, although it can occur in
men.
•Female to male ratio 9:1.
•Usual initial presentation in the 2nd
and 3rd decades of life.
|
General Gross Description
•The gross features of the kidney is
dependent on the severity and chronicity of the lupus nephritis.
•Examples:
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General Microscopic Description
•In the
kidney, the glomeruli are most frequently affected, generally showing a
proliferative/necrotizing glomerulonephritis.
•Other compartments of the
kidney however can also be affected (tubules, interstitium, blood vessels.
•Examples:
|
Clinical Correlation
•The renal manifestations can be nephrotic syndrome, nephritic syndrome,
acute renal failure, and chronic renal failure. The renal manifestations can
be in seen in varying combinations with disease activity of other organ
systems.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. pp 199-208.
•Rose B. Renal Pathophysiology the essentials. Baltimore: Williams and Wilkins, 1994, Ch.9
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| Lupus Nephritis
| | Synopsis by: Harold Yamase M.D. (T71200D38670)[180]
| |