| Acute Transplant Rejection
|
Etiology
•The etiology of organ transplant rejection is complex, basically
immunological.
|
Pathogenesis
•The pathogenic mechanisms are complex, basically
immunological.,
|
Epidemiology
•Transplanted kidney is recognized as foreign by the patient's immune
system.
|
General Gross Description
•Grossly, the kidney may vary from unremarkable to necrotic,
depending on the extent and stage.
•Examples:
|
General Microscopic Description
•The most characteristic changes involve
the arterial vasculature.
•The thickened intima shows inflammatory cell
infiltrates and there may be infiltrates of the muscular walls as
well.
•Occlusive vascular thrombosis may be present.
•Examples:
|
Clinical Correlation
•Patients with
transplanted kidneys are closely monitored and the clinical manifestations
will be that of decreasing renal function.
|
References
•Striker LJ. The renal biopsy. Philadelphia: Saunders, 1990, pp. pp. 232-235.
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| Acute Transplant Rejection
| | Synopsis by: Harold Yamase M.D. (T71000M15600)[189]
| |