Affects all age groups.
There are no identifiable
|General Gross Description|
The kidneys are enlarged and pale and the cortices
may show a petechial or flea-bitten appearance.
|General Microscopic Description|
Idiopathic rapidly progressive glomerulonephritis is a fulminant and
intensely destructive glomeruar disease.
The histologic hallmark of this
form of destruction is widespread crescent development.
glomeruli show exuberant proliferation of epithelial cells in the urinary
Direct immunofluorescence studies are negative.
microscopy the architectural damage and the proliferative features are seen
but the glomerular basement membranes do not show recognizable immune
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 947-8.
Spargo BH. Renal biopsy pathology. New York: Wiley, 1980, pp. 177-190.
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|Synopsis by: Harold Yamase M.D. (T46672M01110)