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Tubular hyaline globules
Etiology

Nephrotic range proteinuria.
Pathogenesis

Plasma protein loss due to glomerular filter disorders leads to reabsorption by the proximal tubular epithelial cells.
The reabsorped proteins appear as hyaline intracytoplasmic droplets.
This histologic alteration is reversible.,
Epidemiology

The epidemiology of nephrotic range proteinuria is diverse, occurring in nephrotic syndrome of any type.
General Gross Description

There are no related gross features. The kidney appears normal.
•Examples:
General Microscopic Description

The proximal tubular epithelial cells show hyaline droplets filling the cytoplasm.
•Examples:
Tubular Epithelial Hyaline Droplets
Clinical Correlation

This histologic change of the proximal tubules is seen in the nephrotic syndrome.
References

Robbins
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 27-28.

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Tubular hyaline globules
Synopsis by: Harold Yamase M.D. (T71200M50060)[186]
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