| Tubular hyaline globules
|
Etiology
•Nephrotic range
proteinuria.
|
Pathogenesis
•Plasma protein loss due to glomerular filter disorders leads
to reabsorption by the proximal tubular epithelial cells.
•The reabsorped
proteins appear as hyaline intracytoplasmic droplets.
•This histologic
alteration is reversible.,
|
Epidemiology
•The
epidemiology of nephrotic range proteinuria is diverse, occurring in nephrotic syndrome of any type.
|
General Gross Description
•There are no related gross features. The kidney
appears normal.
•Examples:
|
General Microscopic Description
•The proximal tubular epithelial cells show hyaline
droplets filling the cytoplasm.
•Examples:
|
Clinical Correlation
•This histologic change of the proximal
tubules is seen in the nephrotic syndrome.
|
References
•Robbins
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 27-28.
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| Tubular hyaline globules
| | Synopsis by: Harold Yamase M.D. (T71200M50060)[186]
| |