|Renal cell adenocarcinoma|
Evidence for genetic factors with association with von Hippel Lindau disease, an abnormality on chromosome 3.
Evidence for environmental factors.
Proliferation of renal tubular cells.,
Renal adenocarcinomas represent 1 to 3 precent of visceral cancers.
Male to female ratio is about 2:1.
Wide age range with peak incidence in the 6th decade of life.
Seen in 20 to 50 percent of patients with von Hippel-Lindau disease.
|General Gross Description|
Tumor may affect any region of the kidney. There is a predilection for the upper pole.
On cut surface, the tumor may be bright yellow and this feature correlates with high lipid content.
A geographic pattern to the cut surface is frequently seen due to ischemia, necrosis, and hemorrhage.
Tumor-parenchymal interface is usually sharp.
Large tumors may distort the calyces and pelvis
Tumor can invade and exit the kidney as renal vein tumor thrombi.
|General Microscopic Description|
Tumor cells may have abundant clear cytoplasm due to lipids and glycogen.
Histologic patterns may be tubular, trabecular or solid.
Tumor is graded on a scale from I to IV depending on cytologic nuclear features.
A sarcomatoid variant is recognized which has a worse prognosis.
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 986-987.
Weiss LM et al: Adult renal epithelial neoplasmx, AJCP, 1995 (103) pp.624-635.
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|Renal cell adenocarcinoma
||Synopsis by: Harold Yamase M.D. (T71000M83123)