| Malignant Rhaboid Tumor
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Etiology
•Unknown.
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Pathogenesis
•Unknown.
•Histogenesis of this tumor is also unknown.,
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Epidemiology
•Mean age at the time of diagnosis is 11 months.
•Male to female ratio:
1.5 to 1.0
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General Gross Description
•Tumors are unilateral, usually less than 500 grams.
•Tumors are soft
and on cut section have a uniform appearance, bulge from the cut surface,
and are well demarcated from the adjacent renal parenchyma. The tumor is
light tan colored.
•Examples:
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General Microscopic Description
•Unlike Wilms tumor, malignant rhabdoid tumors are
monomorphous.
•The tumor is composed of sheets of monotonous round to
ovoid cells.
•The characteristic tumor cells show eccentric nuclei due to
ill-defined pale cytoplasmic inclusion bodes.
•On electron microscopy,
the intracytoplasmic inclusions are due to whorled aggregates of
intermediate filaments.
•Examples:
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References
•Murphy WM, Beckwith JB, and Farrow GM. Tumors of the Kidney, Bladder, and Related Urinary
Structures. Washington, AFIP, 1994.
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| Malignant Rhaboid Tumor
| | Synopsis by: Harold Yamase M.D. (T71000M88003)[236]
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