due to uretero-vesicle incompetence with or without superimposed
Urine outflow obstruction of any kind (calculi, tumor,
prostatic hypertrophy) with superimposed ascending infection.
urine flow causes urinary stasis, providing a medium for bacterial replication.The
infection ascends to the renal parenchyma (often via vesicoureteral reflux) and causes inflammation and
In general, any abnormality to the flow of urine from the
calyces to the urethra increases the risk for pyelonephritis.
|General Gross Description|
There is irregular loss of renal parenchyma with
There is distortion of the associated calyces which commonly
appear dilated because of the reduction in medullary and cortical
The disease process may be unilateral or bilateral and is seen
more frequently involving upper and lower poles of the kidney.
|General Microscopic Description|
affected areas may show dilated tubules filled with colloid-like hyaline
The affected areas may show atrophic tubules
with interstitial fibrosis and chronic inflammation.
The calyceal mucosa
shows chronic inflammation and fibrosis.
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 871-972.
Harrison's Principles of Internal Medicine, 13th Ed: Isselbach et. al. (eds). New York, McGraw-Hill, 1994, pp.543.
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|Synopsis by: Harold Yamase M.D. (T72000M43000)