| Squamous Metaplasia of Bladder
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Etiology
•The etiology of squamous metaplasia is dependent upon the
underlying pathologic process, i.e, bladder calculi, extrophy of the
bladder, schistosomiasis.
•Probably normal in women.
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Pathogenesis
•The normal transitional epithelium will undergo
squamous metaplasia as an adaptive change to chronic irritation, such as
from bladder calculi.,
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Epidemiology
•The epidemiology is dependent on the underlying disease
process.
•Squamous metaplasia is found in a large percentage of women with no abnormalities.
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General Gross Description
•There is no striking gross changes to the epithelial
lining of the bladder.
•There may be a perception that the epithelial
lining is paler and thicker than normal.
•Examples:
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General Microscopic Description
•The normal
transitional epithelium of the bladder is replaced by stratified squamous
epithelium.
•Examples:
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Clinical Correlation
•Squamous metaplasia may occur in situations of chronic
irritation such as bladder calculi, extrophy of the bladder and
schistosomiasis.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 48
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| Squamous Metaplasia of Bladder
| | Synopsis by: Harold Yamase M.D. (T74000M73220)[177]
| |