|Atypical Proliferating Epithelial Neoplasm (Borderline Tumors)|
May derive from surface epithelium of ovary or from endometriotic implants
Increases with increasing age
Upward trend in incidence
15% of all ovarian epithelial neoplasia
|General Gross Description|
The serous and mucinous neoplasms are both cystic and often multicystic.
Papillations may be identified grosly.
Endometrioid and clear cell types are exceedingly rare.
|General Microscopic Description|
Neoplastic cells do not invade the ovarian stroma in these neoplasms.
Mucinous and serous tumors show epithelial stratification, mitotic activity and nuclear atypism also occur.
Serous neoplasms also show the formation of epithelial papillae.
Harlow BL,Epidemiology of borderline ovarian tumors. J Natl Cancer Inst 78(1), 71-74 (1987)
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1067.
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|Atypical Proliferating Epithelial Neoplasm (Borderline Tumors)
||Synopsis by: Melinda Sanders M.D. (T87000M84701)