|
|
|
|
|
|
|
| Mucinous Cystadenocarcinoma | ||
| Etiology • 10% of patients have evidence of ovarian or ovarian-breast cancer syndrome (see pathogenesis) • remainder sporadic | ||
| Pathogenesis • mutations in BRCA1 in a small number of cancer families, | ||
| Epidemiology • peri- or post-menopausal women of low parity • gonadal dysgenesis • ovarian epithelial cancer = 6% of female cancer and 50% of female cancer deaths due to late detection and failure to determine high risk group • mucinous = 10% of ovarian cancers; 20% bilateral | ||
| General Gross Description • capsule generally smooth • partially multicystic partially solid neoplasm • cyst fluid is sticky, yellow, and clear •Examples: | ||
| General Microscopic Description • multiple glands composed of cells containing mucin • reminescent of intestinal adenocarcinoma • nuclear atypia and hyperchromasia with prominent nuclei • invasion of stroma with fibrosis: "desmoplasia" •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1065-1068 This link will directly take you to the relevant new literature Mucinous Cystadenocarcinoma
| Synopsis by: Melinda Sanders M.D. (T87000M84703)[41]
| |
|
|
|
|
|
|