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| Endometrioid Carcinoma | ||
| Etiology • 10% of patients have evidence of ovarian or ovarian-breast cancer syndrome (see pathogenesis) • remainder sporadic • 15-30% associated with synchronous endometrial carcinoma • associated with endometriosis | ||
| Pathogenesis • mutations in BRCA1 in familial cases, | ||
| Epidemiology • peri- or post-menopausal women of low parity • gonadal dysgenesis • ovarian epithelial carcinoma = 6% of female cancer and 50% of female cancer deaths due to late detection and failure to determine high risk group • endometrioid = 20% of ovarian cancers; 40% bilateral | ||
| General Gross Description • smooth or irregular external surface • predominantly solid, although may be partially cystic • white, firm, focally necrotic and hemorrhagic on section •Examples: | ||
| General Microscopic Description • indistinguishable from endometrial carcinoma • glands or glands mixed with solid areas • round to oval vesicular (clear) nuclei with • prominent nucleoli •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1065-1068 This link will directly take you to the relevant new literature Endometrioid Carcinoma
| Synopsis by: Melinda Sanders M.D. (T87000M83803)[42]
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