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| Clear Cell Carcinoma | ||
| Etiology • unknown • associated with endometriosis • unrelated to diethylstilbesterol (DES) exposure | ||
| Pathogenesis • some patients with mutations in BRCA1 , | ||
| Epidemiology • peri- or post-menopausal women of low parity • gonadal dysgenesis • ovarian epithelial carcinoma = 6% of female cancer and 50% of female cancer deaths due to late detection and failure to determine high risk group • clear cell = 6% of ovarian cancers; 40% bilateral | ||
| General Gross Description • smooth, lobulated external surface • usually solid but may be cystic • yellow tan, firm •Examples: | ||
| General Microscopic Description • cells arranged in tubules, nests, or cysts • clear cytoplasm (glycogen rich) with sharply demarcated cell borders • "hobnail" cells with nucleus standing on stalk of cytoplasm • hyperchromatic, pleomorphic nuclei •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1065-1068 This link will directly take you to the relevant new literature Clear Cell Carcinoma
| Synopsis by: Melinda Sanders M.D. (T87000M83103)[43]
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