| Herpes Virus Infection
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Etiology
• Usually Herpes simplex virus type II
• Sexually transmitted
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Pathogenesis
• DNA virus which infects squamous epithelium
• Viral replication results in cytopathic changes in the cell and cell death,
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Epidemiology
• Risks include many sexual partners
• Also partner with many partners
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General Gross Description
• Painful red lesions that blister and then ulcerate
•Examples:
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General Microscopic Description
• Characteristic nuclear enlargement and frequent multinucleation
• Nuclei within the multinucleated cells mold to each other
• Huge intranuclear pink purple inclusions (Cowdry type A)
• Inflamed submucosa with ulceration of the epithelium
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 340-1, 1038.
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| Herpes Virus Infection
| | Synopsis by: Melinda Sanders M.D. (T83000E38500)[277]
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