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| Leiomyoma | ||
| Etiology •unknown | ||
| Pathogenesis •unknown •clonal, estrogen sensitive, | ||
| Epidemiology •extremely common neoplasm affecting 25% of reproductive age women •vast majority are asymptomatic | ||
| General Gross Description •solitary or multiple well circumscribed neoplasms •may be submucosal, intramural or subserosal with pedunculation •whorled, bulging, rubbery, white cut surface •variety of degenerative changes including hemorrhagic, cystic, mucinous, fatty, myxoid, or fibrotic may be found •Examples: | ||
| General Microscopic Description •composed of spindle cells with blunt ended elongate bland nuclei and thin elongated cytoplasm •cells arranged in interlacing bundles •may see cytological atypia which is acceptable in the absence of mitoses •may see necrosis or hemorrhage •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1059-60 This link will directly take you to the relevant new literature Leiomyoma
| Synopsis by: Melinda Sanders M.D. (T85000M88900)[24]
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