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| Leiomyoma (Including Cellular Leiomyoma) | ||
| Etiology •unknown | ||
| Pathogenesis •unknown •clonal, estrogen sensitive, | ||
| Epidemiology •extremely common neoplasm affecting 25% of reproductive age women •vast majority are asymptomatic •Cellular leiomyoma are quite unusual | ||
| General Gross Description •solitary or multiple well circumscribed neoplasms •may be submucosal, intramural or subserosal with pedunculation •whorled, bulging, rubbery, white cut surface •variety of degenerative changes including hemorrhagic, cystic, mucinous, fatty, myxoid, fibrotic may be found •Examples: | ||
| General Microscopic Description •composed of spindle cells with blunt ended elongate bland nuclei and thin elongated cytoplasm •cells arranged in interlacing bundles •Lesion may be intensely cellular with scant cytoplasm •Little atypia or mitoses in cellular leiomyoma •Examples: | ||
| Clinical Correlation •most patients are completely asymptomatic •symptoms, if present, include heavy, painful menses, pelvic fullness, infertility, spontaneous miscarriage, urinary symptoms due to pressure on bladder •estrogen sensitive with occasional rapid growth during pregnancy; atrophy after menopause | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1059-60 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Leiomyoma (Including Cellular Leiomyoma)
| Synopsis by: Melinda Sanders M.D. (T85000M88921)[261]
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