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| Squamous Carcinoma of Cervix | ||
| Etiology •human papillomavirus (HPV) particularly types 16,18,31,33,35 | ||
| Pathogenesis •integration into host genome of HPV with inactivation of p53 •area of active research, | ||
| Epidemiology •sexually transmitted disease particularly affecting young women •increased in cigarette smokers •age peak at 40-45 but dropping •women who have never had a pap smear or have not had one in 5 years | ||
| General Gross Description •usually fungating, may be ulcerated or infiltrative •cut surfaces gray white, hard, poorly circumscribed •necrosis and hemorrhage common •Examples: | ||
| General Microscopic Description •usually non-keratinizing or keratinizing, rarely small cell •sheets or nests with individually keratinized cells or pearls •round to oval nuclei, coarsely granular chromatin •prominent nucleoli •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052-1053 This link will directly take you to the relevant new literature Squamous Carcinoma of Cervix
| Synopsis by: Melinda Sanders M.D. (T83000M80703)[8]
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