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| Adenocarcinoma of Cervix | ||
| Etiology • Associated with human papilloma virus infection, especially type 18. • Account for up to 10% of carcinomas of the cervix | ||
| Pathogenesis •integration into host genome of HPV with inactivation of p53 •area of active research, | ||
| Epidemiology •sexually transmitted disease particularly affecting young women •increased in cigarette smokers •age peak at 40-45 but dropping •women who have never had a pap smear or have not had one in 5 years | ||
| General Gross Description •may be fungating, may be ulcerated but often deeply infiltrative •cut surfaces gray white, hard, poorly circumscribed •necrosis and hemorrhage common •Examples: | ||
| General Microscopic Description • composed of glands with cells containing mucin vacuoles • nuclei are round to oval, hyperchromatic, and have prominent nucleoli •Examples: | ||
| Clinical Correlation • often detected later than squamous carcinoma because location makes pap smear screening more difficult • comparable outcome to squamous carcinoma stage for stage • early stage disease treated with surgery alone; late stage with radiation | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1053. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Adenocarcinoma of Cervix
| Synopsis by: Melinda Sanders M.D. (T83000M81403)[276]
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