| Malignant Melanoma of Vulva
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Etiology
• Unknown in this non-sun exposed area.
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Pathogenesis
• Unknown,
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Epidemiology
• Less than 5% vulvar cancers
• Less than 2% melanomas
• Post-menopausal women
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General Gross Description
• May be reddish plaque or pigmented plaque or nodule
•Examples:
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General Microscopic Description
• Composed of cells which infiltrate the mucosa, may nest at the mucosa-submucosal junction, and infiltrate underlying submucosa.
• Large nuclei, very large nucleoli
• May be epithelioid or spindle
• May have numerous mitotic figures
• Are not cohesive
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1043.
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| Malignant Melanoma of Vulva
| | Synopsis by: Melinda Sanders M.D. (T80100M87203)[268]
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