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| Ganglioneuroblastoma | ||
| Etiology • Unknown | ||
| Pathogenesis • Derives from adrenal medullary precursors. • Neuroblastoma may "mature" to ganglioneuroblastoma with therapy., | ||
| Epidemiology • Usually children under 10. • Occasionally with hypertension or watery diarrhea. • Also termed stroma rich neuroblastoma (Shimada classification). | ||
| General Gross Description • Depends on degree of differentiation. • Well differentiated lesions may be well circumscribed and tan. • Poorly differentiated lesions may resemble hemorrhagic, soft neuroblastomas. •Examples: | ||
| General Microscopic Description • Small cells with darkly hyperchromatic nuclei and scant cytoplasm which may be arranged in rosettes or sheets--neuroblasts • Large cells with large nuclei and prominent nucleoli that resemble ganglion cells. • Well differentiated have only few neuroblasts, intermixed show small nests of neuroblasts, nodular has large masses of neuroblasts •Examples: | ||
| References • Sternberg SS (ed): Diagnostic Surgical Pathology, second edition. Philadelphia, Lippincott-Raven, 1996, pp.589-590. This link will directly take you to the relevant new literature Ganglioneuroblastoma
| Synopsis by: Melinda Sanders M.D. (T93000M94903)[446]
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