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| CNS lymphoma | ||
| Etiology •The etiology of lymphoma is unknown in normal people. •It appears to be related to the to the Epstein Barr virus in immunosuppressed patients such as those with AIDS. | ||
| Pathogenesis •See Etiology. •Primary CNS lymphomas probably do not arise from the resting monocytoid cells, the microglia., | ||
| Epidemiology •In nonimmunosuppressed patients lymphoma makes up 2% of intracranial tumors. This may not seem important but it made up only 1% of intracranial tumors a decade ago. •In AIDS patients it makes up 5% of intracranial lesions. | ||
| General Gross Description •Primary CNS lymphomas are soft, grey-pink masses in the brain often with areas of necrosis or hemorrhage. •They can be any size and can be multifocal. •Examples: | ||
| General Microscopic Description •Primary CNS lymphomas are primarily diffuse, large B cell lymphomas of high grade although other kinds can be seen. •They are often angiocentric leading some to believe they arise in peripheral lymph nodes and are transported to the brain via blood vessels where they become entrapped. •T cell lymphomas do occur but are very rare. •Examples: | ||
| Clinical Correlation •Primary CNS lymphomas act as any mass lesion, causing deficits in the area they invade and increase intra- cranial pressure. •They have a bad prognosis in spite of radiation and chemotherapy. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 658, 1348. • Poirer J et.al. Manual of basic neuropathology. Philadelphia: Saunders, 1990, pp. 177-178. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window CNS lymphoma
| Synopsis by: Dr ML Grunnet (TX2000M95903)[491]
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