|
|
|
|
|
|
|
| Oligodendroglioma | ||
| Etiology •The etiology of the oligodendroglioma is unknown but most tumors show abnormalties of chromosome 19 and 1. | ||
| Pathogenesis •See Etiology., | ||
| Epidemiology •Oligodendrogliomas make up about 5% of intracranial tumors and 10% of gliomas. •They are relatively slow growing except for the anaplastic variety which is rare. | ||
| General Gross Description •Oligodendrogliomas are grey gelatinous masses in the brain that act as mass lesions. •They are more comman in the cerebral hemispheres. •Examples: | ||
| General Microscopic Description •The tumor is made up of uniform oval cells with clear to pale pink cytoplasm and relatively uniform oval to round nuclei that have a fried egg or "box like" appearance. •The stroma is made up of capillaries having a chickenwire appearance between groups of tumor cells. •There is no good grading system and no specific immunoperoxidase stain to identify them. •Examples: | ||
| Clinical Correlation •Oligodendrogliomas act as mass lesions, infiltrating areas of brain. •If they infiltrate the motor area, there are seizures of a focal motor type or hemiparesis. •Infiltrating sensory regions may produce sensory symptoms or misinterpretations. •They also are associated with edema so can produce herniation. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1343-1345. • Poirer J et.al. Manual of basic neuropathology. Philadelphia: Saunders, 1990, pp.26-27. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Oligodendroglioma
| Synopsis by: Dr ML Grunnet (TX2000M94503)[493]
| |
|
|
|
|
|
|