| Hodgkin's Disease, Mixed Cellularity
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Etiology
• Unknown
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Pathogenesis
• Relatively small population of neoplastic cells
• Marked inflammatory reaction driven by cytokines secreted by neoplastic cells includingIL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF,
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Epidemiology
• 0.7% of all new cancers in the U.S. overall for Hodgkin's Disease
• Average age 32 years
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General Gross Description
• Enlarged, flesh gray tan lymph node without well defined nodules or fibrosis
•Examples:
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General Microscopic Description
• Numerous diagnostic Reed Sternberg cells and mononuclear variants which are CD15+, CD30+, CD45-, CD20-
• Mixed population in background of eosinophils, plasma cells, small lymphocytes and histiocytes
•Examples:
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Clinical Correlation
• May present involving multiple lymph node groups
• Responds well to treatment
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References
• Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, 2nd edition, Philadelphia, W.B. Saunders, 1995, pp.166-171.
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| Hodgkin's Disease, Mixed Cellularity
| | Synopsis by: Melinda Sanders M.D. (T08000M96523)[321]
| |