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| Schwannoma | ||
| Etiology • Unknown. | ||
| Pathogenesis • Proliferation of Schwann cells., | ||
| Epidemiology • Sporadic • Generally disease of adults • Associated with sensory nerves, especially the 8th (acoustic neuroma) in an intracranial location, around the spine with extension through the vertebral foramina, or associated with major nerve trunks | ||
| General Gross Description • Encapsulated neoplasms which can be divided from the intact nerve. • Neoplasms are adjacent to nerve which may splay over it • Firm, gray lesions that may have degenerative changes. •Examples: | ||
| General Microscopic Description • Antoni A regions show lining up of delicate wavy nuclei in bands separated by eosinophilic cytoplasm • Rows of nuclei are Verocay bodies • Antoni B regions show less organization. • S-100 reactive. •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1352. This link will directly take you to the relevant new literature Schwannoma
| Synopsis by: Melinda Sanders M.D. (TX0500M95600)[555]
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