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Schwannoma
Etiology

Unknown.
Pathogenesis

Proliferation of Schwann cells.,
Epidemiology

Sporadic
Generally disease of adults
Associated with sensory nerves, especially the 8th (acoustic neuroma) in an intracranial location, around the spine with extension through the vertebral foramina, or associated with major nerve trunks
General Gross Description

Encapsulated neoplasms which can be divided from the intact nerve.
Neoplasms are adjacent to nerve which may splay over it
Firm, gray lesions that may have degenerative changes.
•Examples:
Acoustic Neurinoma (Schwannoma)
General Microscopic Description

Antoni A regions show lining up of delicate wavy nuclei in bands separated by eosinophilic cytoplasm
Rows of nuclei are Verocay bodies
Antoni B regions show less organization.
S-100 reactive.
•Examples:
Schwannoma Schwannoma Schwannoma
Clinical Correlation

Benign lesion treated by surgical resection.
References

Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1352.

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Schwannoma
Synopsis by: Melinda Sanders M.D. (TX0500M95600)[555]
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