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| Malignant Melanoma | ||
| Etiology • Sun exposure. | ||
| Pathogenesis • Proliferation of melanocytes either in the uveal tract (iris, ciliary body and choroid) or in the retina, | ||
| Epidemiology • Incidence is 5% that of melanoma in general • Affects older patients with sun exposure | ||
| General Gross Description • Usually pigmented lesion which may be visible if located anteriorly • Posterior lesions may be detected with change in vision • Malignancy may also be detected after metastatic spread •Examples: | ||
| General Microscopic Description • May be spindle cell or epithelioid • Spindle cell lesions may be relatively bland with little mitotic activity • Epithelioid lesions lesions have large pleomorphic nuclei, prominent nucleoli, variably pigmented cytoplasm and mitotic activity •Examples: | ||
| Clinical Correlation • Outcome dependent on size and cell type • Predilection for liver metastasis. | ||
| References • Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease 5th edition. W.B. Saunders, Philadelphia, 1994, pp. 1180-1. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Malignant Melanoma
| Synopsis by: Melinda Sanders M.D. (TXX000M87203)[351]
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