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| Hodgkins Disease, N.O.S. | ||
| Etiology • Unknown | ||
| Pathogenesis • Neoplastic cell line may be very few in number (LP type) to plentiful (LD) • Inflammatory reaction driven by cytokines secreted by neoplastic cells including IL 5 (attracting eosinophils), IL4, tumor necrosis factor alpha, GM-CSF usually forms bulk of tumor, | ||
| Epidemiology • 0.7% of all new cancers in the U.S. overall • Average age 32 years old | ||
| General Gross Description • Nodes may range from small to large and are fleshy • Some variants show nodularity (LP and NS) • Some variants show fibrosis (LD and NS) •Examples: | ||
| General Microscopic Description • Four major types: nodular sclerosing (NS), lymphocyte predominant (LP), mixed cellularity (MC), and lymphocyte depleted (LD) • All contain diagnostic binucleate Reed-Sternberg cells with eosinophilic macronucleoli • Mononuclear Reed-Sternberg variants differ from subtype to subtype • Background is a mixture of lymphocytes, plasma cells and eosinophils depending on subtype •Examples: | ||
| Clinical Correlation • Most present in cervical lymph nodes • Spread to continguous nodal groups • Generally very responsive to chemotherapy +/- radiation | ||
| References • Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, 2nd edition, Philadelphia, W.B. Saunders, 1995, pp. 141-178 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Hodgkins Disease, N.O.S.
| Synopsis by: Melinda Sanders M.D. (T08000M96503)[323]
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