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| Burkitt's Lymphoma | ||
| Etiology • Epstein-Barr virus infection plays a role in African cases | ||
| Pathogenesis • In EBV associated disease, virus binds CD21 (B cell and oropharyngeal mucosa)and forms episomal latent infection without integration into the host genome. • Cells are immortalized via prevention of apoptosis • However, the step linking this viral infection to chromosome translocations and malignancy is not clear • Translocation with breakpoint on chromosome 8 and chromosome 14 (80% both kappa and lambda light chains), 2 (kappa light chains), and 22 (lambda light chains)is usualy found. • 80% t(8;14)(q24;q32), 20% t(2;8)(p13;q24) or t(8;22)(q24:q11), | ||
| Epidemiology • African population of predominantly male children between 5 and 10 years living within 15 degrees north or south of the equator • Extranodal disease: jaw in African cases with peak at 3 years of age around developing molars; abdominal or pelvic organs particularly bowel in US cases | ||
| General Gross Description • May form large hemorrhagic soft masses •Examples: | ||
| General Microscopic Description • Diffuse infiltrate of cells with moderate amount of cytoplasm and round to oval nuclei • Nuclei contain several prominent nucleoli • Apoptosis and high mitotic rate obvious • Numerous tingible-body macrophages containing lymphocyte debris are seen scattered throughout giving the low power "starry sky" appearance • Surface immunoglobulin, CD19, CD20, CD22, CD10, and CD21 positive (B cell antigens) •Examples: | ||
| Clinical Correlation • Good response to aggressive chemotherapy • Classified as high grade lymphoma | ||
| References • Cotran RS, et.al : Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 640-642, 287-9. • Jaffe ES, Surgical Pathology of the Lymph Nodes and related organs, 2nd edition, Phil, Saunders, 1995, pp.313-319. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Burkitt's Lymphoma
| Synopsis by: Melinda Sanders M.D. (T08000M97503)[330]
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