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| Desmoid | ||
| Etiology •Unknown. | ||
| Pathogenesis •The lesion represents an intermediate between a reparative lesion and a true malignancy., | ||
| Epidemiology •The intra-abdominal variety is associated with pregnancy. •The extra-abdominal variety is seen equally in men and women. •The tumor is common in patients with Gardner's syndrome, a disease associated with a diverse array of neoplastic lesions, including colonic polyps, osteomas and epidermal inclusion cysts. | ||
| General Gross Description •Also known as aggressive fibromatosis. •Lesions characterized by tan-white, poorly demarcated masses. •They are rubbery, firm and blend into the surrounding tissue. •Examples: | ||
| General Microscopic Description •Histologically characterized by active fibroblasts within a dense collagenous matrix. •Mitotic activity is not frequent. •Fragments of skeletal muscle cells can be seen embedded within the tumor. •Examples: | ||
| Clinical Correlation •Desmoids are treated by surgical excision. •Although locally invasive, they rarely metastasize. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 90, 1265. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Desmoid
| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X000M88211)[84]
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