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| Diffuse small lymphocytic lymphoma | ||
| Etiology •Unknown | ||
| Pathogenesis •Unknown, | ||
| Epidemiology •Approximately 4% of all lymphomas fall into this class. | ||
| General Gross Description •Grossly, in common with all lymphomas, the affected gland is enlarged and appears firm and homogenous in consistency. •On cross section, some of the finer details of lymph node architecture may be lost giving rise to a uniform fish-flesh appearance. •Examples: | ||
| General Microscopic Description •Histologically, the node architecture is replaced by uniform small cells which are apparently composed entirely of a nucleus with little cytoplasm. •The nuclear morphology resembles that of normal lymphocytes. •Atypical cells and mitoses are usually not seen. •The cells express mature B lymphocyte markers, and in addition, CD5, a marker associated with T lymphocytes. •Examples: | ||
| Clinical Correlation •The prognosis of small lymphocytic lymphoma diffuse-type is good. •With extension to tissues beyond the lymph node (liver, spleen and bone marrow), spillage of neoplastic cells into blood may occur, with a leukemic picture. •This condition is thus highly similar to chronic lymphocytic leukemia. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 634 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Diffuse small lymphocytic lymphoma
| Synopsis by: T.V.Rajan, M.D., Ph.D. (T08000M96203)[591]
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