| Follicular small cleaved cell lymphoma
|
Etiology
•Unknown
|
Pathogenesis
•Unknown,
|
Epidemiology
•Follicular small cleaved cell lymphoma is one of the
most common non-Hodgkins lymphomas in the United
States, representing approximately 40-50% of all
diagnosed cases.
|
General Gross Description
•Grossly, the lymph nodes are enlarged and multiple
groups of lymph nodes may be affected at the time of
diagnosis.
•Invasion into the surrounding tissue is not seen.
•Involvement of tissues other than lymph nodes is
uncommon with the exception of the bone marrow which is
often involved.
•Examples:
|
General Microscopic Description
•Histologically, there is a tendency for the entire node
to be replaced by follicles composed primarily of small
cells, with scanty cytoplasm and characteristically
cleaved appearing nuclei.
•These cleavages are in the form of infoldings, lines or
deep indentations.
•Mitotic figures are rare in this type of tumor.
•Examples:
|
Clinical Correlation
•The tumor is slow growing and the median survival time
is about 10 years.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 634
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| Follicular small cleaved cell lymphoma
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T08000M96213)[592]
| |