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| Leukemic or Lymphomatous Involvement of Spleen | ||
| Etiology • Etiology that of specific leukemia or lymphoma | ||
| Pathogenesis • Pathogenesis that of specific leukemia or lymphoma, | ||
| Epidemiology • Epidemiology that of specific leukemia or lymphoma | ||
| General Gross Description • May be tiny nodules in B cell areas (low grade follicular lymphoma) • Large, irregular gray tan fleshy nodules (high grade lymphoma) • Multiple gray tan nodules in Hodgkin's disease (uncommon) • Diffuse often massive enlargment with chronic leukemias, esp. myelogenous leukemia •Examples: | ||
| General Microscopic Description • Infiltrates of the neoplastic cell • Leukemias may start as white pulp involvement (lymphocytic) and become diffuse • Lymphomas may show aggregates of neoplastic cells typical of the specific subtype •Examples: | ||
| Clinical Correlation • Very enlarged spleen vulnerable to trauma • May be associated with early satiety as a space occupying lesion • Vulnerable to infarcts with pain • May sequester and/or destroy red blood cells and platelets | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 634-667. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Leukemic or Lymphomatous Involvement of Spleen
| Synopsis by: Melinda Sanders M.D. (T07000M95903)[415]
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