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Fibrosis (Healed Appendicitis) (4X)
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Fibrosis (Healed Appendicitis) (4X)

The mucosa and lumen of the appendix have been replaced by fibrofatty tissue
Portions of the muscularis show fibrous replacement confirming the post inflammatory reparative nature of the lesion
There is no evidence of necrosis or acute inflammation
The original mucosa and lumen can be defined by following muscularis propria (arrow) in its circular course
(Description By:Martin Nadel, M.D. )
(Image Contrib. by:T.V.Rajan, M.D. UCHC )
Healed Appendicitis
Etiology

See acute appendicitis
Pathogenesis

See acute appendicitis,
Epidemiology

See acute appendicitis
General Gross Description

This uncommon lesion commonly resembles a normal appendix on external examination
The lumen shows fibrous obliteration
Some cases with marked fibrosis show mild widening of the appendix with an increased grey white appearance to the serosa
General Microscopic Description

Partial fibrous replacement of the muscularis propria with or without some resolving chronic inflammation is required for the diagnosis as well as fibrous or fibrofatty obliteration of the lumen
Fibrofatty obliteration of the lumen alone is not considered to represent healed appendicitis and its cause is unknown
Clinical Correlation

Healed appendicitis is rarely found, usually in an appendix incidentally removed
A previous history of abdominal pain or symptoms consistent with undiagnosed acute appendicitis can often be elicited
References

Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 823-824
Healed Appendicitis
Synopsis by: Martin Nadel M.D. (T66000M49000)[193]
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