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Luteoma (40X)
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Luteoma (40X)

The nuclei are round and regular with small nucleoli.
The chromatin pattern is unremarkable and the nuclear outlines are delicate.
The cytoplasm is abundant, eosinophlic, and vacuolated.
(Description By:Melinda Sanders, M.D. )
(Image Contrib. by:Melinda Sanders, M.D. UCHC )
Pregnancy Luteoma
Etiology

Pregnancy
Pathogenesis

HCG induced proliferation of stromal cells
? pre-existent endocrine dysfunction,
Epidemiology

Reproductive age group
African American
Multiparous
May be associated with virilism of mother(25%)
Virilized infants in 2/3 of virilized mothers
General Gross Description

May be yellow, brown or gray
Solid or with areas of hemorrhage
May be multiple
General Microscopic Description

Luteinized large cells with abundant eosinophilic cytoplasm
Nuclei are regular
Clinical Correlation

Benign, may recur in subsequent pregnancies.
References

Blaustein's Pathology of the Female Genital Tract, 4th ed. Kurman RJ (ed). New York: Springer-Verlag, 1994, pp. 495-497.
Clement PB,Tumor-like lesions of the ovary associated with pregnancy. Int J Gynecol Pathol, 1993, 12(2), 108-115.
Pregnancy Luteoma
Synopsis by: Melinda Sanders M.D. (T87000M86100)[272]
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