| Keloid
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Etiology
•A keloid is exuberant scar formed in response to
trauma.
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Pathogenesis
•In a normal scar formation, the fibroblasts bridge the
edges of a wound and permit the epithelium to grow over.
•A normal scar is usually a linear structure, often
depigmented and below the level of the surrounding skin.
•In a keloid, however, there is disproportionate
proliferation of fibroblasts giving rise to masses of
collagenous tissue.
•The scar therefore protrudes above the surface of the
surrounding skin.,
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Epidemiology
•More common in dark-skinned individuals
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General Gross Description
•A large often tender scar, protruding above the level
of the surrounding skin.
•Examples:
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General Microscopic Description
•Histologically, it is characterized by the presence of
numerous proliferating fibroblasts and
large amounts of dense, deeply eosinophilic-staining
collagen.
•Examples:
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Clinical Correlation
•No clinical significance
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 90
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| Keloid
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T01000M49720)[521]
| |