| Dermatofibrosarcoma
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Etiology
•Unknown
|
Pathogenesis
•Unknown,
|
Epidemiology
•An uncommon lesion usually on the trunk of middle-aged
individuals.
|
General Gross Description
•Also known as dermatofibrosarcoma protubrans.
•It may present as a series of bumps or nodules on top
of a plaque-like lesion.
•Superficial ulceration of some of these nodules may be
a presenting feature.
•Examples:
|
General Microscopic Description
•Histologically, the lesion represents a low-grade
fibrosarcoma of soft tissue origin.
•The proliferating fibroblast of this lesion have a
tendency to be arranged in a radially distributed
manner, often referred to as "storiform" pattern.
•The lesion may have mitotic figures, but the frequency
is often low to undetectable.
•Examples:
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Clinical Correlation
•Clinically, the lesion is a slow growing malignancy
requiring wide local excision for cure.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1189
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| Dermatofibrosarcoma
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T01000M88323)[518]
| |