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| Sjogren's Syndrome | ||
| Etiology •Unknown | ||
| Pathogenesis • Lymphocytic infiltration of salivary and lacrimal glands followed by destruction of normal tissue and fibrosis • CD4+ T cells in infiltrate; autoantibodies in circulation including rheumatoid factor (75%), ANA (>50%), and anti-ribonucleoprotein antibodies including SS-A(Ro) and SS-B (La) which are most common, | ||
| Epidemiology • Most are women between 40 and 60 | ||
| General Gross Description • Rarely see glands but fleshy and enlarged initially then atrophic and fatty •Examples: | ||
| General Microscopic Description • Lymphocytic infiltrates in periductal and perivascular regions early • Coalesce to form sheets of lymphocytes with follicle formation • Eventual atrophy of duct structures, fatty replacement and fibrosis •Examples: | ||
| Clinical Correlation • Present with dry eyes and dry mouth (keratoconjunctivitis and xerostomia) • Isolated disorder is sicca syndrome; secondary to variety of autoimmune diseases esp rheumatoid arthritis • Ulceration of cornea with inflammation due to lack of tears • Dry, fissured mouth and ulcerated nose which may perforate | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 208-210. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Sjogren's Syndrome
| Synopsis by: Melinda Sanders M.D. (T55100M72240)[332]
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