| Pleomorphic Adenoma
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Etiology
• Unknown
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Pathogenesis
• Arise either from myoepithelial cell or reserve cell,
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Epidemiology
• Increased risk after radiation treatment
• Most common benign neoplasm of salivary gland
• Most common neoplasm of parotid
• Present between 40-60 years of age
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General Gross Description
• Firm, gray, sometimes glassy neoplasm
• Appears well circumscribed, although may have infiltrative borders microscopically
•Examples:
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General Microscopic Description
• Epithelial proliferation arranged in a variety of patterns including ductules, strands, or sheets
• Variable stroma including a palely basophilic loose (myxoid) appearance
• May be foci of cartilage or bone
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 749-750.
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| Pleomorphic Adenoma
| | Synopsis by: Melinda Sanders M.D. (T55100M89400)[325]
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