| Adenocarcinoma
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Etiology
• Unknown.
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Pathogenesis
• May follow the adenoma-carcinoma sequence as discussed in the description of colon adenocarcinoma
• May complicate Crohn's disease or Peutz-Jegher's syndrome,
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Epidemiology
• May occur in Lynch syndrome, type II
• Usually elderly patients
• Approximately 50% in duodenum in periampullary region
• An order of magnitude less frequent than colon carcinomas
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General Gross Description
• Duodenal lesions are often papillary consistent with origin in villous adenoma
• More distal lesions may be obstructing or may be ulcerated
•Examples:
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General Microscopic Description
• Intestinal type carcinomas with neoplastic cells forming glands, some of which show cribriform configuration with central necrosis and inflammation
• Elongated, hyperchromatic nuclei with nucleoli
•Examples:
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References
• Rosai J: Ackerman's Surgical Pathology. 8th
ed. St. Louis, Mosby-YearBook, 1996, pp. 686.
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| Adenocarcinoma
| | Synopsis by: Melinda Sanders M.D. (T64000M81403)[535]
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