| Adenocarcinoma
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Etiology
Unknown.
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Pathogenesis
May follow the adenoma-carcinoma sequence as discussed in the description of colon adenocarcinoma
May complicate Crohn's disease or Peutz-Jegher's syndrome,
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Epidemiology
May occur in Lynch syndrome, type II
Usually elderly patients
Approximately 50% in duodenum in periampullary region
An order of magnitude less frequent than colon carcinomas
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General Gross Description
Duodenal lesions are often papillary consistent with origin in villous adenoma
More distal lesions may be obstructing or may be ulcerated
Examples:
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General Microscopic Description
Intestinal type carcinomas with neoplastic cells forming glands, some of which show cribriform configuration with central necrosis and inflammation
Elongated, hyperchromatic nuclei with nucleoli Examples:
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References
Rosai J: Ackerman's Surgical Pathology. 8th
ed. St. Louis, Mosby-YearBook, 1996, pp. 686.
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| Adenocarcinoma
| | Synopsis by: Melinda Sanders M.D. (T64000M81403)[535]
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