|
|
|
|
|
|
|
| Adenocarcinoma | ||
| Etiology • Unknown. | ||
| Pathogenesis • May follow the adenoma-carcinoma sequence as discussed in the description of colon adenocarcinoma • May complicate Crohn's disease or Peutz-Jegher's syndrome, | ||
| Epidemiology • May occur in Lynch syndrome, type II • Usually elderly patients • Approximately 50% in duodenum in periampullary region • An order of magnitude less frequent than colon carcinomas | ||
| General Gross Description • Duodenal lesions are often papillary consistent with origin in villous adenoma • More distal lesions may be obstructing or may be ulcerated •Examples: | ||
| General Microscopic Description • Intestinal type carcinomas with neoplastic cells forming glands, some of which show cribriform configuration with central necrosis and inflammation • Elongated, hyperchromatic nuclei with nucleoli •Examples: | ||
| Clinical Correlation • Duodenal lesions discovered with occlusion of biliary and/or pancreatic drainage • Distal lesions often discovered at an advanced stage as liquid contents can progress past tight obstruction | ||
| References • Rosai J: Ackerman's Surgical Pathology. 8th ed. St. Louis, Mosby-YearBook, 1996, pp. 686. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Adenocarcinoma
| Synopsis by: Melinda Sanders M.D. (T64000M81403)[535]
| |
|
|
|
|
|
|