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| Adenocarcinoma and Carcinoid Neoplasms of Appendix | ||
| Etiology • Unknown | ||
| Pathogenesis • Presumably derive from basal cell which in the case of adenocarcinoids can undergo neurosecretory and mucinous differentiation, | ||
| Epidemiology • Carcinoid tumor is most common neoplasm of appendix (1/300 incidental appendectomies) • Adenocarcinoids which secrete both mucin and contain neurosecretory granules may behave as low grade malignancies • Mucinous cystadencarcinomas of appendix also occur. | ||
| General Gross Description • Carcinoid tumors are yellow tan solid masses, usually well circumscribed. • Mucinous cystadenocarcinomas may exhibit lumenal mucous as well as a gelatinous, white, glassy appearance on section. • Other adenocarcinomas may be hard and gray white. •Examples: | ||
| General Microscopic Description • Adenocarcinoids may be exclusively tubular or may be admixed with typical carcinoid patterns. • Mucinous neoplasms that are malignant should show invasion into the wall and/or neoplastic cells in peritoneal deposits of mucin • Other adenocarcinomas may resemble typical intestinal adenocarcinomas or rarely signet ring carcinomas. •Examples: | ||
| Clinical Correlation • Course depends on tumor type; adenocarcinoids are usually indolent • Mucinous carcinomas may result in gelatinous ascites with adhesions • Other forms of adenocarcinoma may behave like typical right sided colon cancers | ||
| References • Rosai J: Ackerman's Surgical Pathology. 8th ed. St. Louis, Mosby-YearBook, 1996, pp. 720-4. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Adenocarcinoma and Carcinoid Neoplasms of Appendix
| Synopsis by: Melinda Sanders M.D. (T66000M82403)[606]
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