| Focal Nodular Hyperplasia
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Etiology
•Focal nodular hyperplasia has been associated with the
ingestion of oral contraceptives.
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Pathogenesis
•Unknown,
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Epidemiology
•It is significantly more common in
younger women than in men.
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General Gross Description
•Grossly, the lesion consists of a single nodule,
anywhere within the liver parenchyma,
usually clearly demarcated from the rest of the liver,
but lacking a well defined capsule.
•Typically, there is a prominent central depressed scar
with radiating bands extending from
the scar into the remainder of the nodule.
•The nodule is often paler than the
surrounding parenchyma.
•Examples:
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General Microscopic Description
•The central scar (see gross description) contains a
large blood vessel with a prominent muscular wall.
•The radiating septae contain branches of this large
blood vessel, which often demonstrate concentric or
eccentric thickening of the wall by muscular hyperplasia.
•The liver cells between the fibrous septae usually are
normal in appearance.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 878
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| Focal Nodular Hyperplasia
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T56000M72000)[492]
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