Production of autoimmune antibodies to many self antigens
especially antinuclear antibodies.
Production of antibodies to kidney
antigens plus the accumulation of circulating immune complexes in the
glomeruli lead to renal injury.,
predominantly a disease affecting women, although it can occur in
Female to male ratio 9:1.
Usual initial presentation in the 2nd
and 3rd decades of life.
|General Gross Description|
The gross features of the kidney is
dependent on the severity and chronicity of the lupus nephritis.
|General Microscopic Description|
kidney, the glomeruli are most frequently affected, generally showing a
Other compartments of the
kidney however can also be affected (tubules, interstitium, blood vessels.
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. pp 199-208.
Rose B. Renal Pathophysiology the essentials. Baltimore: Williams and Wilkins, 1994, Ch.9
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|Synopsis by: Harold Yamase M.D. (T71200D38670)