| Bicuspid Aortic Valve
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Etiology
•Congenital
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Pathogenesis
•Unknown for the congenital lesion.
•Acquired subsequent calcific stenosis attributed to
"wear and tear" mechanisms with hemodynamic changes
attributed to deformities.,
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Epidemiology
•Affects 1-2% of the population.
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General Gross Description
•The two cusps are about equal in size. One of the two
cusps is bisected into two deformed cusps by a thick
fold extending from the annulus to the free margin, as
if there were 3 cusps at first, one large and two
smaller ones with fusion of the commissure between
the two small ones.
•Fibrosis and extensive calcification may ensue
causing a severe aortic stenosis. The resulting
calcific deposits and excrescences can be very
deforming.
•Examples:
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General Microscopic Description
•Fibrosis, hyalinization, and calcified amorphous
matter are noted. The pathology is not that of
arteriosclerosis or usual dystrophic calcification,
which is not usually deforming.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 545.
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| Bicuspid Aortic Valve
| | Synopsis by: J Hasson, MD (T39000M24570)[367]
| |